| Fr, 17.12.21 19:00 | ||||
| FC-Astoria Walldorf | - | VfB Stuttgart II | 1:1 (1:1) | |
| TSG Hoffenheim II | - | FC 08 Homburg | 2:1 (2:0) | |
| Sa, 18.12.21 14:00 | ||||
| 1. FSV Mainz 05 II | - | SG Sonnenhof Großaspach | 2:0 (0:0) | |
| Bahlinger SC | - | VfR Aalen | 2:2 (0:2) | |
| FC RW Koblenz | - | SV 07 Elversberg | 0:2 (0:1) | |
| FK 03 Pirmasens | - | FC Gießen | 2:1 (0:0) | |
| KSV Hessen Kassel | - | FSV Frankfurt | 0:0 (0:0) | |
| SSV Ulm 1846 Fußball | - | Kickers Offenbach | 1:0 (1:0) | |
| TSV Schott Mainz | - | TSV Steinbach Haiger | 3:3 (1:0) | |
| Platz | Verein | Spiele | S | U | N | Tore | Differenz | Punkte |
|---|---|---|---|---|---|---|---|---|
| 1 |  SSV Ulm 1846 Fußball |
22 | 14 | 4 | 4 | 38:22 | 16 | 46 |
| 2 |  1. FSV Mainz 05 II |
22 | 15 | 1 | 6 | 37:25 | 12 | 46 |
| 3 |  Kickers Offenbach |
21 | 14 | 2 | 5 | 39:14 | 25 | 44 |
| 4 |  SV 07 Elversberg |
21 | 12 | 5 | 4 | 48:21 | 27 | 41 |
| 5 |  TSV Steinbach Haiger |
22 | 11 | 7 | 4 | 37:27 | 10 | 40 |
| 6 |  FC 08 Homburg |
22 | 10 | 5 | 7 | 30:30 | 0 | 35 |
| 7 |  Bahlinger SC |
21 | 10 | 3 | 8 | 22:23 | -1 | 33 |
| 8 |  KSV Hessen Kassel |
22 | 8 | 6 | 8 | 29:24 | 5 | 30 |
| 9 |  VfR Aalen |
22 | 9 | 3 | 10 | 35:42 | -7 | 30 |
| 10 |  TSG Balingen |
21 | 8 | 3 | 10 | 30:38 | -8 | 27 |
| 11 |  TSG Hoffenheim II |
22 | 7 | 5 | 10 | 33:34 | -1 | 26 |
| 12 |  FC-Astoria Walldorf |
22 | 7 | 5 | 10 | 34:41 | -7 | 26 |
| 13 |  FC RW Koblenz |
22 | 6 | 7 | 9 | 24:30 | -6 | 25 |
| 14 |  VfB Stuttgart II |
22 | 6 | 6 | 10 | 31:33 | -2 | 24 |
| 15 |  FK 03 Pirmasens |
22 | 6 | 6 | 10 | 21:32 | -11 | 24 |
| 16 |  FSV Frankfurt |
22 | 5 | 7 | 10 | 26:31 | -5 | 22 |
| 17 |  FC Gießen |
22 | 6 | 4 | 12 | 20:29 | -9 | 22 |
| 18 |  SG Sonnenhof Großaspach |
22 | 5 | 5 | 12 | 26:48 | -22 | 20 |
| 19 |  TSV Schott Mainz |
22 | 4 | 4 | 14 | 21:37 | -16 | 16 |
